Manchester, New Hampshire, is rapidly emerging as a center for artificial intelligence (AI) innovation, with a growing number of companies leveraging AI to transform industries and enhance daily life.
Leading AI Companies in Manchester
Several local firms are at the forefront of this technological wave:
BioAI Health Inc.
Located at 1662 Elm St, BioAI Health specializes in using AI to improve disease diagnosis and predict patient responses to therapy. Their platform integrates complex data sets from translational studies and clinical trials, developing machine learning models on multi-omic data to anticipate patient reactions and drug resistance.
Calexus Solutions
Based at 795 Elm St, Calexus Solutions offers AI and data consulting services through their Swarmalytics platform. They assist home builders in combining artificial and natural intelligence, providing a comprehensive approach to data-driven growth. Their services include data creation, AI-based modeling, and campaign execution.
Silknet Software Inc.
Operating from 50 Phillippe Cote St, Silknet Software provides customer experience automation solutions via their open CCaaS platform. By leveraging data, AI, and bots, they help businesses gain new insights, enhance customer experiences, and reduce engagement costs.
AI Consulting and Automation Services
In addition to product-focused companies, Manchester hosts firms offering AI consulting and automation services:
HummingAgent
Serving the Manchester area, HummingAgent provides AI automation solutions to businesses, reporting an average cost reduction of 66% for their clients. Their services include Private GPT deployments, agentic workflows, and intelligent chatbots, transforming business operations.
EvolveNova
EvolveNova delivers AI-powered solutions and web development services in Manchester. They specialize in creating voice and text chatbots, AI-driven summarization tools, predictive analytics, and automation solutions tailored to business needs.
Community Initiatives and Support
The New Hampshire Tech Alliance (NHTA) plays a pivotal role in fostering the state’s tech ecosystem. In July 2025, NHTA launched the New Hampshire AI Task Force, bringing together representatives from government, industry, academia, and the community to guide responsible AI development and influence public policy across the state.
As Manchester continues to embrace AI, the collaboration between innovative companies and supportive community initiatives positions the city as a burgeoning hub for technological advancement, promising significant benefits for local businesses and residents alike.

